Internal Beam Radio Therapy/Brachytherapy II-46
More About Brachytherapy II-46
Technical Scope of Brachytherapy II-47
Systemic Radioisotope Therapy (RIT) II-47
Radiation Therapy for Treating Oral Cancer II-47
Other Forms of Radiation Therapy II-48
Photoradiation Therapy (PRT) II-48
Photodynamic Therapy (PDT) II-48
Cost of Radiation Therapy II-48
Limitations of Conventional Radiation Therapy Techniques II-48
Overview of Radiotherapy Equipment II-49
External Beam Therapy Devices II-49
CyberKnife II-49
Gamma Knife II-49
TomoTherapy II-50
LINACs II-50
Comparison of Select Radiotherapy Systems II-50
Proton Therapy Devices II-51

7. PRODUCT OVERVIEW II-52
Introduction II-52
Landmarks in Evolution of Cancer Care II-52
Linear Accelerator II-52
Accelerator - Down to Nuts & Bolts II-52
Clinical Demands and Device Characteristics II-53
Dual X-ray Energy Linear Accelerator - Numerous Energy
Offerings II-54
Price - A Direct Functionality of Features II-54
Beam Energy and Dose Rates - Deciding Factors II-54
Isocentric Units - The Prevalent Form in Accelerators II-54
Subsystem Design Factors II-55
Bending Magnet Systems - For Smooth Functioning II-55
Dosimetry System - Regulating the Radiation Dosage II-55
Beam Steering Systems - Directing the Flow II-56
Cobalt-60 II-56
Characteristics of Cobalt-60 Machines II-56
Major features of Cobalt-60 Radioisotope II-56
Competitive Edge: Cobalt 60 Units vs. Linear Accelerators II-57
Comparative Assessment of Cobalt-60 Teletherapy Units and
Linear Accelerators II-57
Benefits of LINACs over Cobalt 60 Units II-58
Treatment Planning System: An Innovative Technique in
Radiation Therapy II-58
Radiation Therapy Simulator II-59
CT Simulation Systems II-59
Major Systems of Radiation Therapy Simulator II-60
Mechanical Systems II-60
Principles of Operations II-61

8. RADIOTHERAPY ACCESSORIES II-62
Introduction II-62
Tumor Localization and Treatment Simulation Devices II-62
Patient Restraint and Repositioning Devices II-62
Different Types of Patient Restraint and Repositioning Devices II-63
Patient Targeting System II-63
Field-Shaping Devices II-63
Dose-Modifying Devices II-64
Treatment Setup and Delivery Devices II-65
Breast Bridge with a Rolling-Ball Angle Inclinometer II-65
Squeeze Bridge Device II-65
Beam Alignment Device II-66
Arm Board II-66
Tilt Board II-66
Shoulder Reactor II-66
Mylar Window Table Insert II-66
Clamps II-66
Treatment Verification and Quality Assurance Devices II-66
Need for Surgery and Radiotherapy Likely to Diminish II-67

9. CANCER THERAPY - EPIDEMIOLOGY II-68
Four Progressive Stages of Cancer II-68
Types of Cancer II-68
Breast Cancer II-69
Treatment Options II-69
Major Developments in the Treatment Area of Breast Cancer II-69
Colorectal Cancer II-70
Prostate Cancer II-70
Pancreatic Cancer II-71
Cervical Cancer II-71
Esophageal Cancer II-71
Lung Cancer II-71
Treatment Options Available II-72
Technological Developments II-72
Cures II-72
Enhanced Therapies II-72
Prevention and Public Awareness II-72
Better Screening and Earlier Detection II-72
Other Emerging Therapies II-73

10. CANCER TREATMENT - A COST ANALYSIS II-74
Table 28: Cancer Treatment Costs by Modality II-74
Medicare and Medicaid Reimbursement II-74
Coverage II-75
Coding II-75
Payment II-75

11. NEW FRONTIERS IN RADIATION THERAPY II-76
Increasing Role of Imaging in Treatment Planning II-76
MRI to Attain Optimum Outcomes II-76
Positron Emission Tomography II-76
Convergence of PET and CT Images for Treatment Planning II-76
Dynamic contrast-enhanced CT/MRI II-77
Copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) PET (Cu-
ATSM PET) II-77
Four-Dimensional CT Scanning II-77
4D Adaptive Radiation Therapy - Adds a New Dimension II-77
MRI-Linacs - To Revolutionize Cancer Care II-78
Nano Particles in Cancer Treatment II-78
Microbeam Radiation Therapy Revisited II-79
Unleashing the Power of Plasma II-79
ION Beam Therapy Gains Attention II-80
Volumetric Modulated Arc Therapy (VMAT) II-80
Mobetron™ - Radiation Therapy on the Wheels II-80
3-D Conformal Radiation Therapy: A New Technology II-81
World's First 3-D Image-Guided Radiation Therapy System from
Elekta II-81
Evolving Technology Arms TomoTherapy with an Edge over
Competition II-81
High Dose Radiation Treatment Found to Reduce Side Effects in
Prostate Cancer Treatment II-82

12. PRODUCT INNOVATIONS/INTRODUCTIONS II-83
National Institute for Health and Care Excellence Introduces
INTRABEAM radiotherapy II-83
IBA Inks Collaboration Agreement with Mobius Medical Systems II-83
Mirada Medical Enters into Agreement with RefleXion Medical
for Research Collaboration II-83
Radyalis and NVIDIA Announce Research Collaboration II-83
IBA Releases OmniPro I'mRT + Software II-83
Elekta Launches Advanced Versa HD Linear Accelerator System II-83
Ion Beam Applications (IBA) Unveils COMPASS 3.0 Plan
Verification System II-84
Alfred Health's WBRC Introduces Brainlab ExacTrac Adaptive
Gating System for Cancer Therapy II-84
Elekta Unveils New Monaco 5.0 Fully Integrated Radiation
Treatment Planning System II-84
Accuray Launches New TomoTherapy® H™ Series Technology II-84
Accuray and MIM Software to Launch Co-branded Version of
Mobile MIM 3.0 II-84
MIM Launches Upgraded Mobile MIM 3.0 II-84
Elekta Launches New Monaco® 3.0 DCA Treatment Planning System II-84

13. RECENT INDUSTRY ACTIVITY II-85
iCAD Takes Over Radion and DermEbx II-85
Elekta Gains Approval from Japanese Ministry of Health for
Versa HD II-85
Elekta Gains U.S. FDA 510(k) Approval for new Versa HD System II-85
The Christie NHS Foundation Trust Joins Consortium for
Developing MRI-guided Radiation Therapy System II-85
University Medical Center Installs First-ever MRI-guided
Radiation Therapy System II-85
The Netherlands Cancer Institute-Antoni van Leeuwenhoek
Hospital Joins Elekta and Royal Philips Consortium II-85
University of Texas MD Anderson Cancer Center Trust Joins
Elekta and Royal Philips Consortium II-86
Oncology Services International Takes Over Upstate Linac Services II-86
RTS Acquires OnCure Holdings II-86
Equra Health and Elekta Ink Long-term Agreement II-86
Radiation Oncology Resources and McKesson Specialty Health
Sign Multi-year Agreement II-86
Elekta Secures Order for Versa HD Systems from St. James's
Institute of Oncology II-86
RaySearch Laboratories and Hitachi Medical Sign Distribution
Agreement II-87
Spire Healthcare Enters into Partnership with Elekta II-87
RaySearch Laboratories Announces Research Collaboration with
Brainlab II-87
Oncology Services International Enters into Partnership with
D3 Oncology Solutions II-87
Oncology Systems and IBA Dosimetry Sign Distribution Agreement II-87
Ion Beam Applications Partners Apollo Hospitals to Establish
Proton Therapy Center II-87
Froedtert & The Medical College of Wisconsin Clinical Cancer
Center Joins Consortium for Developing MRI-guided Radiation
Therapy System II-88
Sunnybrook Health Sciences Centre Joins Consortium for
Developing MRI-guided Radiation Therapy System II-88
Varian Obtains FDA 510(k) Authorization for RapidPlan
Radiotherapy Treatment Planning Tool II-88
Varian Medical Systems Enters into Partnership with Siemens
Healthcare II-88
Accuray to Take Over Morphormics II-88
e2v Bags Contract from Accuray II-88
Northern Centre for Cancer Care to Purchase TrueBeam™ Devices
from Varian II-89
Elekta Signs MoU with MSM-MEDIMPEX II-89
Institut Curie Selects Radiotherapy Systems of Varian Medical
Systems II-89
Varian Medical Systems Establishes Subsidiary in South Korea II-89
NHS Supply Chain Enters into Agreement with Elekta II-89
Elekta Takes Over Radon II-89
Varian Bags Order to Equip Proton Therapy Facility II-89
Varian Medical Systems Secures SFDA Approval for UNIQUE™
Medical Linear Accelerator II-90
Mevion Medical Systems Receives FDA Approval for MEVION S250
Proton Therapy System II-90
Accuray Inks Agreement with German Cancer Research Center II-90
Nordion Announces Launch of Gamma Centre of Excellence II-90

14. FOCUS ON SELECT KEY PLAYERS II-91
Accuray Incorporated (US) II-91
BrainLab (Germany) II-91
Elekta AB (Sweden) II-91
Nucletron B.V. (The Netherlands) II-92
GE Healthcare (UK) II-92
Hitachi America (US) II-93
IBA Group (Belgium) II-93
Mitsubishi Electric Corporation (Japan) II-94
Nordion, Inc. II-94
Philips Healthcare (US) II-95
RaySearch (Sweden) II-95
Sumitomo Heavy Industries Ltd. (Japan) II-95
Varian Medical Systems, Inc. (US) II-96

15. GLOBAL MARKET PERSPECTIVE II-97
Table 29: World Recent Past, Current & Future Analysis for
Radiation Therapy Equipment by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Middle East &
Africa and Latin American Markets Independently Analyzed with